New generation of barbed suture with self-locking system available in different molecules, absorbable and non-absorbable, and available in different sizes: unidirectional with final lock system, unidirectional without final lock system, two way double needle, two way with center pointer, loop. Suitable for different surgical procedures where running suture technique is required. Functional, fast and safe. It does not require knots, it guarantees a high tightness with a constant stress distribution along the section of approximation of tissues.